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目的探讨参芪扶正注射液对皮肌炎的疗效及对患者肿瘤坏死因子-α(TNF-α)的影响。方法 85例皮肌炎患者为受试对象,随机分成中西结合组(45例)与西药组(40例)两组。记录其治疗前后TNF-α因子变化情况及治疗后不良反应发生情况,对比两种方法的具体临床治疗效果。结果 1治疗后中西结合组TNF-α水平为(1.30±0.33)mg/L,低于西药组的(1.48±0.34)mg/L,组间对比差异具有统计学意义(P<0.05);2中西结合组总有效率为93.33%,明显高于西药组的77.50%,组间对比差异具有统计学意义(P<0.05)。结论对皮肌炎患者采用中西合并疗法,疗效确切,可有效降低TNF-α水平,具有临床推广价值。
Objective To investigate the effect of Shenqi Fuzheng injection on dermatomyositis and its effect on tumor necrosis factor-α (TNF-α). Methods Eighty-five patients with dermatomyositis were randomly divided into two groups: Chinese-Western combination group (45 cases) and Western medicine group (40 cases). The change of TNF-α and the incidence of adverse reactions after treatment were recorded before and after treatment, and the specific clinical effects of the two methods were compared. Results 1 After treatment, the level of TNF-α in the combination group was (1.30 ± 0.33) mg / L, which was lower than that in the western medicine group (1.48 ± 0.34) mg / L, the difference was statistically significant (P <0.05); 2 The total effective rate of Chinese-Western combination group was 93.33%, which was significantly higher than that of Western medicine group (77.50%). The difference between the two groups was statistically significant (P <0.05). Conclusion Western and Western combined therapy for patients with dermatomyositis, curative effect is exact, can effectively reduce the level of TNF-α, with clinical promotion value.