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观察氯沙坦对30例老年高血压病患者的降压作用,及对血清脂质、尿酸代谢、肾功能等的影响。患者停用以往降压药物,采用自身对照法,给予氯沙坦片(20—50)mg/d,治疗4周后测定24h血压、尿蛋白、血尿酸、血脂、血钾及空腹血糖浓度,以及肌酐、尿素氮含量。患者血压从(23.45±0.2/16.77±4.19)kPa,降至(13.1±1.19/12.43±0.03)kPa,24h尿蛋白、肌酐清除率下降;血尿酸亦显著降低,血清脂质、尿素氮、肌酐、血钾、空腹血糖均无明显改变。氯沙坦对老年高血压病患者有良好的降压作用,且能促进其尿酸排泄,降低血尿酸浓度,对肾功能无不良影响。
To observe the antihypertensive effects of losartan on 30 elderly patients with hypertension and its effects on serum lipid, uric acid metabolism, renal function and so on. Patients discontinued previous antihypertensive drugs and losartan tablets (20-50) mg / d were administered by self-control. Blood pressure, proteinuria, blood uric acid, serum lipids, serum potassium and fasting plasma glucose were measured at 4 weeks after treatment. And creatinine, urea nitrogen content. The blood pressure decreased from (23.45 ± 0.2 / 16.77 ± 4.19) kPa to (13.1 ± 1.19 / 12.43 ± 0.03) kPa, and the urinary albumin and creatinine clearance rate decreased in 24 hours. Serum lipids, serum urea nitrogen, creatinine , Serum potassium, fasting blood glucose no significant change. Losartan has a good antihypertensive effect on elderly patients with hypertension, and can promote uric acid excretion, reduce serum uric acid concentration, no adverse effects on renal function.