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1972年～1984年,日本有1700名儿童在Kobe大学和东京市立儿童医院接受肾活检。其中有37例诊断为FSGS。这些病儿均有蛋白尿,共分为三组进行随防。第一组有11例,仅表现为无症状性蛋白尿。第二组有14例,开始无临床症状,以后发展为肾病综合征。第三组有32例,均有肾病综合征。三组病例在性别、年龄、早期肾功能、高血压、血尿发生率和病理变化上均无显著差异。第一组在病理分型中,周边型1例、中央型9例、中央型+周边型1例。第二组中,周边型1例、中央型12例、中央型+周边型1例。第三组:周边型10例、中央型19例、中央型+周边型2例、不能分型1例。随防2～10年,三组的12例周边型FSGS无1例发生肾功能衰竭,而三组的44例中央
From 1972 to 1984, 1,700 children in Japan underwent kidney biopsy at Kobe University and Tokyo Municipal Children’s Hospital. Among them, 37 cases were diagnosed as FSGS. These sick children have proteinuria, divided into three groups with the prevention. The first group of 11 patients showed only asymptomatic proteinuria. The second group of 14 patients, no clinical symptoms began later developed into nephrotic syndrome. The third group of 32 patients, all with nephrotic syndrome. There was no significant difference between the three groups in gender, age, early renal function, hypertension, incidence of hematuria and pathological changes. The first group in the pathological type, peripheral type in 1 case, central type in 9 cases, central type + peripheral type in 1 case. The second group, peripheral type in 1 case, central type in 12 cases, central type + peripheral type in 1 case. The third group: peripheral type in 10 cases, 19 cases of central type, central type + peripheral type in 2 cases, can not type in 1 case. With prevention of 2 to 10 years, 12 cases of peripheral FSGS in the three groups had no renal failure, while 44 cases in the three groups