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我院从1991年以来采用MBDIS方法系统观察并指导化疗,提高了我院白血病患者的完全缓解率。现将观察结果报告如下。病例和方法观察病例共40例,按1986年天津会议关于急白分型的修改建议,计有急淋5例,急非淋35例(其中M_1、M_2共24例,M_4、M_510例,M_61例),化疗前骨髓白血病细胞中位数0.66(0.42～0.92)。1991年5月至1992住院成人急白24例,初治20例,复治4例,按MBDIS指导化疗作为治疗组。1989至1991年4月住院成人急白病例16例,初治15例,复治1例,均用原方案2～4个疗程作为对照组。急淋最初月COP方案和VDP方案,每疗程4周;急非淋主要采用HA,DA,HOAP,次为AA(阿霉素和阿糖胞苷)COAP。治疗组按MBDIS改换和继用原方案,对照组均不按MBDI改变方案,MBDIF和MBDIS均按孙氏
Our hospital has used MBDIS method to systematically observe and guide chemotherapy since 1991, and improve the complete remission rate of leukemia patients in our hospital. The observations are reported below. Cases and methods were observed in 40 cases, according to the 1986 meeting of Tianjin Conference on acute white classification of the proposed changes, there are acute leaching 5 cases, acute non-leaching 35 cases (including M_1, M_2 24 cases, M_4, M_510 cases, M_61 Cases), the median bone marrow leukemia cells before chemotherapy 0.66 (0.42 ~ 0.92). From May 1991 to May 1992, 24 cases of acute hospitalization were admitted to hospital, 20 cases were initially treated and 4 cases were retreated. MBDIS-guided chemotherapy was used as the treatment group. From April 1989 to April 1991, 16 cases of acute white hospitalization, 15 cases of initial treatment and 1 case of retreatment were used as the control group. Acute lymph and COPD program on the first month of the VDP program, each course of 4 weeks; acute non-parin use of HA, DA, HOAP, followed by AA (doxorubicin and cytarabine) COAP. Treatment group by MBDIS change and follow the original program, the control group are not MBDI change program, MBDIF and MBDIS are Sun