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癫痫是小儿神经系统常见疾病之一,发生率约为7‰[1]。抗癫痫药是治疗小儿癫痫重要而有效的手段,长期使用抗癫痫药导致不同系统的不良反应已引起临床的重视。1968年Kruse首先报告了服用抗癫痫药可造成骨病,这些损害表现为亚临床的骨代谢障碍、骨生化指标异常、易骨折、身材矮小等[2]。近年来,随着多种抗癫痫药物的广泛应用,许多学者
Epilepsy is one of the common diseases of the nervous system in children, the incidence is about 7 ‰ [1]. Antiepileptic drugs is an important and effective treatment of pediatric epilepsy, long-term use of antiepileptic drugs lead to adverse reactions of different systems has caused clinical attention. In 1968, Kruse first reported that taking antiepileptic drugs can cause bone disease, these lesions manifested as subclinical bone metabolism disorder, abnormal bone biochemical indicators, easy to fracture, short stature [2]. In recent years, with a wide range of antiepileptic drugs widely used, many scholars