暴露于宣威现场的小鼠体内芳烃羟化酶活性的变化

• 作 者: 尹先仁 梁超轲 郑璐霞 吴志宏
• 机 构: 环境卫生监测所,环境卫生与卫生工程研究所,环境卫生与卫生工程研究所,环境卫生监测所,
• 出 处: 卫生研究
• 发表日期: 1987年02期
• 关键词: 宣威 芳烃羟化酶 小鼠肺癌 活性水平 燃柴 煤组 肺癌发生率 活性关系 发生数 酶活性

本文测定了暴露于宣威肺癌现场的小鼠体内芳烃羟化酶(AHH)活性变化,并观察到AHH活性水平与肺癌之间的联系。实验结果指出,燃煤组小鼠的肺和肝AHH活性最高,小鼠肺癌发病数亦高,这与燃煤空气中B(a)P浓度有关;燃柴组小鼠的酶活性和肺癌发生数居中;对照组最低。表明AHH活性高低可反映机体接触PAH的水平。

In this study, changes in aromatase hydroxylase (AHH) activity in mice exposed to Xuanwei lung cancer were measured and the association between AHH activity and lung cancer was observed. The results of the experiment indicated that the lung and liver AHH activity in the coal-burning group was the highest, and the incidence of lung cancer in mice was also high, which was related to the concentration of B (a) P in the coal-fired air. The activity of the enzyme and lung cancer Number in the middle; the lowest control group. That the level of AHH activity may reflect the level of body contact with PAH.