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本文对１０１名低、无应答儿童采用不同方案加强免疫，进行随机对照前瞻性研究观察，表明，对母亲ＨＢｓＡｇ阳性的低、无应答婴幼儿采用注射分枝杆菌多糖与乙肝疫苗（３０μｇ×３）联合应用，免后１年抗体阳转率可达９０％左右；对母亲ＨＢｓＡｇ阴性的低、无应答婴幼儿采用加强１支１０μｇ乙肝疫苗，可使近一半婴幼儿产生抗－ＨＢｓ。利用ＰＣＲ检测低、无应答者的ＨＢＶ－ＤＮＡ，仅有３８５％为ＨＢＶ感染者，母亲为ＨＢｓＡｇ阳性者的无应答婴幼儿若不进行加强免疫，仍存在着ＨＢＶ感染的危险性。
In this paper, 101 low and non-responders children with different programs to enhance immunity, a randomized controlled prospective study showed that mothers with low, non-responsive mothers and mothers injections of Mycobacterium tuberculosis polysaccharide and hepatitis B vaccine (30μg × 3) Combined application, 1 year after immunization rate of antibody positive rate of up to 90%; mother of HBsAg-negative low, no response to infants and young children with a 10μg hepatitis B vaccine, can make nearly half of infants and young children produce anti-HBs. Using PCR to detect low and non-responders HBV-DNA, only 3 85% of HBV-infected mothers non-HBsAg-positive infants and young children without enhanced immunity, there is still the risk of HBV infection.