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食管及胃静脉曲张出血是肝硬化病情进展过程中最为凶险的并发症之一,随着相关医疗技术及药物的应用,出血病人的病死率显著下降。但是,如何规范、科学的对出血病人实施个性化综合治疗,以最大程度地改善病人预后,成为一项重要的循证医学研究课题。2000年英国胃肠病学会根据当时已发表的相关系统评价文章及临床研究结果制定了《英国肝硬化病人静脉曲张出血治疗指南》,具有重要的临床治疗指导意义并得到了广泛的应用,2015年英国胃肠病学会结合近年来的基础及临床研究结果,更新了指南中的部分内容。
Esophageal and gastric variceal bleeding is one of the most dangerous complications in the progress of cirrhosis. With the application of medical technology and drugs, the mortality of bleeding patients is significantly decreased. However, how to standardize and scientifically carry out personalized integrated treatment for bleeding patients to maximize the prognosis of patients has become an important subject of evidence-based medicine research. In 2000, the British Society of Gastroenterology developed the Guide to the Treatment of Variceal Hemorrhage in Liver Cirrhosis Patients in England based on published systematic reviews and clinical studies published at the time, which has important guiding significance for clinical treatment and has been widely used in 2015 British Gastroenterology Association in recent years based on the results of basic and clinical research, updated some of the guidelines.