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肿瘤的多药耐药(MDR)是导致肿瘤化疗失败的最常见因素,P糖蛋白介导MDR是MDR最重要途径也是研究最透彻的途径。目前所用的P糖蛋白介导MDR逆转剂临床效果欠佳,从海洋寻找新的P糖蛋白介导MDR逆转剂已经成为研究热点。介绍了近年来从各种海洋生物中提取的各种具备P糖蛋白介导MDR抑制活性的化合物。研究表明,海洋天然产物以其新颖结构和生物活性强的特点逐步成为P糖蛋白介导的第三代逆转剂的新来源。
Tumor multidrug resistance (MDR) is the most common cause of tumor chemotherapy failure, P-glycoprotein mediated MDR is the most important MDR pathway is also the most thorough way. The currently used P glycoprotein mediated MDR reversal agent clinical effect is poor, from the ocean to find a new P glycoprotein mediated MDR reversal agent has become a research hot spot. In recent years, various compounds with P glycoprotein-mediated MDR inhibitory activity extracted from various marine organisms are introduced. Studies have shown that marine natural products with its novel structure and strong biological activity has gradually become a new source of P glycoprotein-mediated third generation of reverse agents.