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目的探讨对于口服降糖药物不能很好控制血糖的2型糖尿病(T2DM)患者,改为甘精胰岛素针联合阿卡波糖片治疗的临床疗效。方法收集口服降糖药物控制不佳的2型糖尿病患者共60例,分为甘精胰岛素治疗组(A组)及预混胰岛素针治疗组(B组)各30例,A组采用甘精胰岛素针联合阿卡波糖治疗,B组采用预混胰岛素针单用治疗,观察两种方法治疗前后血糖的变化、胰岛素用量、血糖达标时间、低血糖发生率。结果两组患者经治疗后血糖均明显下降。A组与B相比较血糖更加容易平稳,血糖达标时间短,胰岛素用量偏少,低血糖发生率低,差异具有统计学意义(P<0.05)。结论甘精胰岛素针联合阿卡波糖片治疗T2DM疗效安全有效,适宜作为口服降糖药物不能良好控制的2型糖尿病患者的首选治疗方法。
Objective To investigate the clinical efficacy of insulin glargine combined with acarbose in patients with type 2 diabetes mellitus (T2DM) whose oral hypoglycemic agents can not control blood sugar well. Methods A total of 60 type 2 diabetic patients with poorly controlled oral hypoglycemic agents were enrolled in this study. The patients were divided into insulin glargine group (A group) and premixed insulin needle group (B group), 30 cases each. Group A received insulin glargine Acupuncture combined with acarbose treatment, B group with premixed insulin needle treatment alone, before and after treatment to observe the two methods of blood glucose changes, insulin dosage, blood glucose compliance time, the incidence of hypoglycemia. Results After treatment, the blood glucose of the two groups were significantly decreased. Compared with group B, blood glucose was more stable in group A, blood glucose was shorter, the amount of insulin was lower, and the incidence of hypoglycemia was lower, with statistical significance (P <0.05). Conclusion Glargine and acupuncture combined with acarbose in the treatment of T2DM is safe and effective, which is suitable as the preferred treatment for type 2 diabetes patients whose oral hypoglycemic agents are not well controlled.