Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of it＇s gene

• 作 者: Zhi-MingHao Jin-YanLuo JinChen
• 机 构: DepartmentofGastroenterology,DepartmentofGastroenterology,不详
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2003年1期
• 关键词: 核糖酶 端粒酶 反义转录酶 基因克隆 肿瘤治疗学 基因疗法
• 基金项目: 国家自然科学基金

AIM: To design a hammerhead ribozyme targeting humantelomerase reverse transcriptase (hTERT) and clone it's genefor future use in the study of tumor gene therapy.METHODS: Using the software RNAstructure, the secondarystructure of hTERT mRNA was predic