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Objectives To observe the electr-ophysiologic effects of propafenone (Prop) on ischemic ventricular tachyarrhythmias. Methods A canine is-chemic ventricular tachyarrhythmia model was estab-lished in open-chest dogs subjected to programmed electrical stimulation (PES) on 5～8 days after acute myocardial infarction. The electrophysiologic effects of propafenone were observed in the model. Results Propafenone distinctly lengthened the QTc interval (P > 0.01) and effective refractory period (ERP) of normal and ischemic ventricular myocardium (NERP and IERP) respectively (P > 0.01), decreased the dispersion of ERP in ischemic myocardium and in left ventricle (P > 0.01), and increased the diastolic excitability threshold of normal and ischemic ventricular myocardium remarkably (P > 0.01). Pro-pafenone effectively prevented PES-induced ventricu-lar tachycardia (VT) or ventricular fibrillation (VF) (P > 0.01) and ischemia-induced VT/VF (P > 0.05). Conclusions The results indicated that the canine model produced by our methods is a worthy and reliable one, propafenone may be effective in prevent-ing the onset of VT / VF after myocardial ischemic damage in dogs, and deserve further attention as an antifibrillatory agent.
Objectives To observe the electro- ophysiologic effects of propafenone (Prop) on ischemic ventricular tachyarrhythmias. Methods A canine is-chemic ventricular tachyarrhythmia model was estab-lished in open-chest dogs subjected to programmed electrical stimulation (PES) on 5- 8 days after acute myocardial infarction. The electrophysiologic effects of propafenone were observed in the model. Results Propafenone distinctly lengthened the QTc interval (P> 0.01) and effective refractory period (ERP) of normal and ischemic ventricular myocardium (NERP and IERP) respectively ), decreased the dispersion of ERP in ischemic myocardium and in left ventricle (P> 0.01), and increased the diastolic excitability threshold of normal and ischemic ventricular myocardium remarkably (P> 0.01). Pro-pafenone effectively prevented PES-induced ventricu-lar Tachycardia (VT) or ventricular fibrillation (VF) (P> 0.01) and ischemia-induced VT / VF (P> 0.05). Conclusions The results indicated that the ca nine model produced by our methods is a worthy and reliable one, propafenone may be effective in prevent-ing the onset of VT / VF after myocardial ischemic damage in dogs, and deserve further attention as an antifibrillatory agent.