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目的采用糖皮质激素联合雷公藤多苷作为该病的治疗药物,探讨应用效果,为临床治疗提供参考和借鉴。方法选取2014年9月至2015年3月间原阳县红十字医院收治的紫癜性肾炎患儿,共计74例。随机分配法均分为治疗组37例与对照组37例,对照组仅采用糖皮质激素药物进行治疗,治疗组在上述内容基础上采用雷公藤多苷进行治疗,对比各自疗效。结果治疗组中显著例数22例,好转例数14例,无效1例,有效率97.3%;对照组中显著例数11例,好转例数16例,无效10例,有效率73.0%。对比两组患者有效率发现,治疗组优于对照组,两组患者具有显著性差异,P<0.01。治疗组胃部不适1例;治疗组胃部不适4例,肝脏损伤5例;对比发现两组患者于不良反应发生情况方面差异具有统计学意义,P<0.05。结论糖皮质激素联合雷公藤多苷是一种有效治疗儿童紫癜性肾炎的临床方案。作为中西医药物联合使用的范例,本次研究过程中未见患者出现严重药物不良反应,该方案值得推广和深入研究。
Objective To use glucocorticoid combined with tripterygium glycosides as the treatment of the disease, explore the application effect, provide a reference for clinical treatment. Methods A total of 74 children with purpura nephritis admitted to the Red Cross Hospital of Yuanyang County from September 2014 to March 2015 were selected. Random allocation method was divided into treatment group 37 cases and control group 37 cases, the control group only treated with glucocorticoid drugs, the treatment group on the basis of the above, the treatment with tripterygium glycosides, compared their respective curative effect. Results In the treatment group, there were 22 significant cases, 14 cases improved, 1 case ineffective and 97.3% effective. In the control group, 11 cases were significant, 16 cases improved, 10 cases ineffective, and the effective rate was 73.0%. Comparing the effective rate of two groups of patients, the treatment group was superior to the control group, with significant difference between the two groups (P <0.01). One case of stomach discomfort in the treatment group; 4 cases of stomach discomfort in the treatment group, and 5 cases of liver injury. The differences between the two groups in the incidence of adverse reactions were statistically significant (P <0.05). Conclusion Glucocorticoid combined with tripterygium glycosides is an effective clinical treatment for purpuric nephritis in children. As an example of joint use of Chinese and Western medicine, no serious adverse drug reactions occurred in the course of this study. The program deserves promotion and in-depth study.