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目的 研究血锌原卟啉 (ZPP)和血清转铁蛋白受体 (sTfR)测定在合并感染的缺铁性贫血患儿中的诊断价值。方法 1999～ 2 0 0 2年华中科技大学同济医学院附属同济医院采用血液荧光测定仪测定ZPP ,酶联免疫吸附试验法测定血清转铁蛋白受体 ,检测了 6 0例合并常见感染性疾病的缺铁性贫血 (IDA)患儿 ,设为感染合并IDA组 ,Hb( 70 4± 2 1 7)g/L。同时检测了 2 0例患同类感染性疾病的血红蛋白正常患儿 ,设为对照组 ,Hb( 12 3 1± 10 2 ) g/L。结果 ZPP :对照组为 ( 0 5 4± 0 18) μmol/L ,而感染合并IDA组为 ( 2 5 5± 1 72 ) μmol/L ,明显高于对照组 ( t=8 71,P <0 0 0 1)。血清转铁蛋白受体 :对照组为 ( 7 0 9± 2 32 )mg/L ,感染合并IDA组为 ( 2 4 4 0± 17 84 )mg/L ,亦显著高于对照组 (t =7 33,P <0 0 0 1)。结论 两种诊断IDA的新指标ZPP和sTfR受感染因素的影响较小 ,在合并常见感染性疾病的IDA患儿中 ,仍可作为诊断铁缺乏的良好指标
Objective To investigate the diagnostic value of ZPP and sTfR in children with iron deficiency anemia complicated by infection. Methods From 1999 to 2002, Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology used ZFP to measure serum ZPP. Serum transferrin receptor was detected by enzyme-linked immunosorbent assay (ELISA), and 60 patients with common infectious diseases Children with iron deficiency anemia (IDA) were enrolled in the IDA cohort with Hb (70 4 ± 2 1 7) g / L. At the same time, 20 normal hemoglobin children with similar infectious diseases were detected and set as control group, Hb (12 3 ± 10 2) g / L. Results Compared with the control group, the level of ZPP was (0 54 ± 0 18) μmol / L in the control group and (25 ± 1 72) μmol / L in the IDA group 0 0 1). Serum transferrin receptor was (709 ± 232) mg / L in the control group and (2440 ± 1784) mg / L in the IDA group, which was also significantly higher than that in the control group (t = 7 33, P <0 0 0 1). Conclusions The two new markers for diagnosis of IDA, ZPP and sTfR, are less affected by the infectious agents and may still be a good indicator of iron deficiency in IDA patients with common infectious diseases