论文部分内容阅读
目的了解和掌握近3年细菌性痢疾病原体菌群分布动态及耐药性特点,为指导基层医疗机构合理用药提供科学依据。方法依据《全国细菌性痢疾监测方案》进行样品采集、检验和分析。结果昌平区近3年志贺菌以D群宋内志贺菌为主,占54.65%;其次为B群福氏志贺菌占38.37%;A群痢疾志贺菌占5.81%;C群鲍氏志贺菌占1.16%。其中B群福氏志贺菌血清亚型以F4为主,占45.45%,其次为x亚型占24.24%,F2亚型占15.15%,F1亚型占12.12%,y亚型占3.03%;福氏志贺菌对头孢唑啉、头孢噻肟、庆大霉素、左氧氟沙星等药物敏感,宋内志贺菌对左氧氟沙星敏感率最高为97.87%,其次为氧氟沙星、环丙沙星、诺氟沙星、阿莫西林、头孢唑啉、头孢噻肟;痢疾志贺菌对氨苄西林、头孢唑啉、萘啶酸、四环素、头孢噻吩5种药物耐药。结论 D群宋内志贺菌取代了以往的B群福氏志贺菌;B群福氏志贺菌F4亚型取代了以往的福氏F2a亚型,成为新的流行血清型;基层医疗机构应根据本地区药敏结果合理选择抗菌药物。
Objective To understand and grasp the bacterial distribution of bacterial pathogens in recent 3 years and drug resistance characteristics, to provide guidance for grass-roots medical institutions to provide a scientific basis for rational drug use. Methods According to the “National Bacterial dysentery monitoring program” for sample collection, testing and analysis. Results Shigella was mainly Shigella sonnei in group D in the past three years in Changping district, accounting for 54.65%; followed by Shigella flexneri in group B, accounting for 38.37%; Shigella flexneri in group A accounted for 5.81% Shigella spp. Accounted for 1.16%. Among them, serogroup F was dominant in F4, accounting for 45.45%, followed by 24.24% in x subtype, 15.15% in F2 subtype, 12.12% in F1 subtype and 3.03% in y subtype. Shigella flexneri susceptible to cefazolin, cefotaxime, gentamicin, levofloxacin and other drugs, Shigella sonnei sensitive to levofloxacin up to 97.87%, followed by ofloxacin, ciprofloxacin, Norfloxacin, amoxicillin, cefazolin, cefotaxime; Shigella dysenteriae resistant to ampicillin, cefazolin, nalidixic acid, tetracycline, cefalotin five kinds of drug resistance. Conclusion Group D Shigella sonnei replaced the previous group B Shigella flexneri; Group B Shigella flexneri B group F4 subtype replaced the previous F2a subtype of Fufang, a new epidemic serotypes; grass-roots medical institutions Antimicrobial drugs should be selected according to the susceptibility results in this area.