伊班磷酸钠治疗恶性肿瘤骨转移性骨痛的临床研究

• 作 者: 刘文超 张燕军 任军 范黎 尤向辉 黄若宇 黄颍 斯晓明 潘伯荣
• 机 构: 第四军医大学西京医院肿瘤中心,第四军医大学西京医院肿瘤中心,第四军医大学西京医院肿瘤中心,第四军医大学西京医院肿瘤中心,第四军医大学西京医院肿瘤中心,第四军医大学西京医院肿瘤中心,第四军医大学西京医院
• 出 处: 第四军医大学学报
• 发表日期: 2004年14期
• 关键词: 伊班磷酸钠 骨肿瘤/继发性 疼痛

目的 :评价伊班磷酸钠治疗恶性肿瘤骨转移引起的骨痛及其不良反应 .方法 :将 1 8例恶性肿瘤骨转移骨痛的患者 ,采用随机、阳性对照方法 ,随机分为治疗组 (组A ,n =8)用伊班磷酸钠 4mg ,阳性对照组 (组B ,n =1 0 )用帕米磷酸二钠90mg ,均单次iv滴注 ,观察 2 1d评价止痛效果 .结果 :1 8例入组患者 ,均可评价疗效和不良反应 .组A患者 ,有效率 4 / 8;组B患者 ,有效率 3/ 1 0 .组A 4例有效患者 ,3～ 6 (平均 4 .5 )d起效 ,观察期间均无复发 ;组B 3例有效患者 ,6～ 9(平均 7.5 )d起效 ,2例于治疗后 1 1～ 1 4 (平均 1 2 .5 )d复发 .不良反应组B为发热 ,组A主要是恶心呕吐、骨肌肉疼痛、水肿和手足麻木等 ,但发生率较低 ,程度均轻 .结论 :伊班磷酸钠对恶性肿瘤骨转移所引起的骨痛具有一定的治疗作用 ,耐受性良好 .

Objective: To evaluate the effects of ibandronate on bone pain and its adverse reactions induced by bone metastasis of malignant tumor.Methods: 18 cases of malignant bone metastases and bone pain were randomly divided into treatment group A, n = 8) with ibandronate 4mg, positive control group (group B, n = 10) with pamidronate 90mg, a single iv drip, observed 21d evaluation of analgesic effect.Results: 1 The efficacy and adverse reactions of 8 patients were evaluated in group A. The response rate was 4/8 in group A and 3/10 in group B. Group A was effective in 4 patients, 3 to 6 (mean, 4.5) ) d, no recurrence during the observation period. Group B 3 effective patients, 6 to 9 (average 7.5) d onset, 2 patients after treatment 11 ~ 14 (average 12.5) d recurrence. Group B was fever, Group A was mainly nausea and vomiting, bone muscle pain, edema and numbness of hands and feet, but the incidence was low and the degree was light.Conclusion: Ibandronate had the following effects on bone pain caused by bone metastasis of malignant tumors: Certain therapeutic effect, well tolerated.