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目的:为进一步加深铁转运刺激因子(stimulatorofFetransport,SFT)对机体铁代谢以及铁代谢异常(缺乏或超载)的理解,综述了国内外对SFT的研究进展,重点讨论了SFT的表达分布与结构、生理功能、表达调控及其表达异常与脑铁代谢疾病关系。资料来源:应用计算机检索http://www.ncbi.nlm.nih.gov/PubMed与SFT相关文献,检索词“stimulatorofirontransport”和“stimulatorofFetransport”,并限定文献语种为英文。同时计算机检索中文CNKI(中国期刊网全文数据库)1997-01/2004-10相关文献,检索词“脑铁代谢,铁转运刺激因子”,并限定文献语种为中文。资料选择:对资料进行筛选,以关于SFT的结构及其与脑铁代谢疾病相关的文献作为纳入标准。资料提炼:共收集到20篇关于SFT及1300篇关于脑铁代谢的文献,21篇文献符合纳入标准。资料综合:从入选的21篇文献中,综述了目前对SFT的表达分布与结构、生理功能、表达调控及其表达异常与脑铁代谢疾病关系等方面的研究进展。结论:SFT具有刺激细胞表面的非转铁蛋白结合铁或转铁蛋白结合铁的摄取功能,其基因表达存在转录水平和转录后水平两种调控机制,主要受细胞内铁浓度的负向调控。SFT可能在脑铁代谢中具有重要作用。
OBJECTIVE: To further understand the understanding of iron metabolism and iron metabolism (lack or overloading) of iron transport stimulator of Fetransport (SFT), the research progress of SFT at home and abroad is reviewed. The distribution and structure of SFT are mainly discussed. Relationship Between Physiological Function, Expression and Regulation, Abnormal Expression and Brain Metabolic Diseases. Source: Using computer to search http://www.ncbi.nlm.nih.gov/PubMed and SFT related literature, the terms “stimulatorofirontransport” and “stimulatorofFetransport”, and the limited language is English. At the same time, the computer searches Chinese CNKI (Chinese Journal Net Full-text Database) from January 1997 to October 2004 with related articles, search term “brain iron metabolism, iron transport stimulating factor”, and the limited literature language is Chinese. Data Selection: Data were screened to include the structure of SFTs and their associated literature on brain iron metabolism. DATA EXTRACTION: A total of 20 articles on SFT and 1,300 articles on brain iron metabolism were collected and 21 articles met the inclusion criteria. DATA SYNTHESIS: The 21 literature reviewed the current research progress on the relationship between SFT expression distribution and structure, physiological function, expression and regulation and its expression abnormality and brain iron metabolism disease. CONCLUSIONS: SFT has the function of stimulating the uptake of non-transferrin-bound iron or transferrin-bound iron on the cell surface. Its gene expression exists in both transcriptional and post-transcriptional regulatory mechanisms and is mainly regulated by the negative regulation of intracellular iron concentration. SFT may play an important role in brain iron metabolism.