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T淋巴细胞是参与气道炎症的重要细胞,其活化与哮喘迟发相反应(LAR)关系密切。本研究旨在观察小剂量茶碱对过敏性哮喘患者抗原激发后的LAR和T淋巴细胞活化的影响。 作者将17例轻度过敏性哮喘患者(FEV_1％>80％)随机分为两组,分别给予氨茶碱或安慰剂治疗,疗程6周,茶碱组平均血药浓度6.6μg/ml。治疗前后进行过敏原激发试验,同时取外周血和支气管肺泡灌洗液(BALF)计数细胞总数和分类,并用流式细胞仪分析T淋巴细胞。实验是在双盲情况下进行的。 结果 同安慰剂组相比,茶碱组治疗后的LAR期
T lymphocytes are important cells involved in airway inflammation and their activation is closely related to delayed response to asthma (LAR). The purpose of this study was to investigate the effect of low-dose theophylline on the activation of LAR and T lymphocytes after antigen challenge in allergic asthma. The authors randomized 17 patients with mild allergic asthma (FEV 1%> 80%) to two groups and received aminophylline or placebo respectively for 6 weeks. The mean serum concentration of theophylline group was 6.6 μg / ml. Allergen challenge test was performed before and after treatment. The total number and classification of cells in peripheral blood and bronchoalveolar lavage fluid (BALF) were counted and the T lymphocytes were analyzed by flow cytometry. The experiment was conducted in a double-blind situation. Results Compared with placebo, theophylline group LAR after treatment