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内皮素能延长心肌细胞动作电位时间，诱发早期后除极。已证明几种药物有抗内皮素性心律失常作用。内皮素的心脏电生理活性对冠心病猝死的发生可能有重要意义．
Endothelin can prolong cardiomyocyte action potential time, induce early depolarization. Several drugs have been shown to have anti-endothelin-induced cardiac arrhythmias. The electrophysiological activity of endothelin on cardiac arrest may be of great significance.