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人类T细胞病毒Ⅰ (HTLV Ⅰ )导致成人T淋巴细胞白血病 (ATL) ,其中病毒编码的蛋白Tax起主要作用。Tax主要通过CREB/ATF和NF κB两条途径 ,最终导致多种细胞基因的改变 ,引起细胞的恶性转化和增生
Human T cell virus (HTLV I) causes adult T-cell leukemia (ATL), of which the virally encoded protein Tax plays a major role. Tax mainly through the CREB / ATF and NF κB two ways, eventually leading to a variety of cellular gene changes, causing malignant transformation and proliferation of cells