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1,4-二羟基-5,8-双({2-[(2-羟乙基)氨基]乙基}氨基)-9,10-蒽酮二盐酸盐(DHAD)是蒽环属抗生素阿霉素的类似物,对某些动物肿瘤有显著的抗肿瘤活性。初步研究表明,DHAD对心脏毒性比阿霉素小。对四例以前未用过DHAD的病人(其中三例在用药前三周曾接受过化疗),用DHAD治疗肉瘤、脂肉瘤、肺小细胞癌和肾细胞癌。所有病人肝和肾功能均正常,肌酸酐<2mg%,胆红素<2mg%。每个病例用DHAD剂量为12mg/m~2,在100ml5%葡萄糖中静脉滴注35分钟。滴注前先取血样,滴注结束后开始150分钟内分别收集0,5,10,15,30,40,60,90,120和150
1,4-Dihydroxy-5,8-bis ({2 - [(2-hydroxyethyl) amino] ethyl} amino) -9,10-anthrone dihydrochloride (DHAD) is an anthracycline antibiotic Adriamycin analogues have significant anti-tumor activity on certain animal tumors. Preliminary studies have shown that DHAD is less cardiotoxic than doxorubicin. Four patients who had not had DHAD in the past (three received chemotherapy three weeks prior to treatment) were treated with DHAD for sarcoma, liposarcoma, small cell lung cancer, and renal cell carcinoma. All patients with normal liver and kidney function, creatinine <2mg%, bilirubin <2mg%. Each case with DHAD dose of 12mg / m ~ 2, 100ml5% glucose intravenous infusion of 35 minutes. Blood samples were taken prior to instillation and were collected for 0, 5, 10, 15, 30, 40, 60, 90, 120 and 150