论文部分内容阅读
环孢素A(CsA)是由真菌Talypocladiuminflatum培养液中分离得到的由11个氨基酸组成的中性环多肽混合物,作为一种免疫抑制剂主要用于器官移植的抗排异反应和移植物抗宿主病。近年来也用于许多已知或可能由自身免疫引起的疾病的治疗。由于在治疗剂量下,其药动学的个体差异及机体对
Cyclosporine A (CsA) is a mixture of neutral amino acids peptides consisting of 11 amino acids isolated from the fungal Talypocladiumin flatum culture. As an immunosuppressant, it is mainly used in organ transplantation anti-rejection and graft versus host disease. In recent years it has also been used in the treatment of many diseases known or likely to be caused by autoimmunity. Because of the therapeutic dose, the pharmacokinetics of individual differences and body pairs