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本文采用放射免疫法对20例非溃疡性消化不良(NUD)患者和10例正常人在基础状态和饮水后5分钟进行了血清胃泌素和血浆血管活性肠肽(VIP)的测定。结果显示:NUD组空腹胃泌素浓度(39.45±13.14ng/L)较正常组(25.40±8.73ng/L)高,差异有显著性(P<0.05)。两组空腹及饮水后5分钟血浆VIP浓度均无显著性差异。提示胃泌素在NUD发病机理中起一定作用,体循环血浆VIP则无明显作用。
In this paper, 20 patients with non-ulcer dyspepsia (NUD) and 10 normal subjects were tested for serum gastrin and plasma vasoactive intestinal peptide (VIP) by radioimmunoassay in the basal state and 5 minutes after drinking. The results showed that the fasting serum gastrin concentration in NUD group was significantly higher than that in normal group (39.45 ± 13.14ng / L, 25.40 ± 8.73ng / L, P <0.05). There were no significant differences in plasma VIP concentrations between the two groups in five minutes after fasting and drinking. Gastrin prompted a certain role in the pathogenesis of NUD, systemic plasma VIP has no significant effect.