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放射线阻光造影剂引起血浆内组织胺浓度增高早已被人们熟悉。造影剂引起的反应同注射组织胺的反应特征类似,虽仍不知其真正原因,但这种类似组织胺的反应只能是组织胺所引起。鼠主动脉研究中还发现泛影葡胺曾引起血管内皮损伤。血和造影剂混合液比单纯造影剂对内皮的损伤要大,当实验性颈动脉血管造影时,血脑屏障紊乱的部位常发生矛盾现象即造影对侧血脑屏障发生渗透紊乱现象有时比造影同侧要严重得多。如术前使用抗组织胺药物可以完全消除造影剂被血或水稀释后的各种反应。血和造影剂混合液引起损伤的特点同组织胺释放所引起的极相似。由于抗组织胺对纯造影剂引起的内皮泄漏无任何作用,故造影剂直接作用于主动脉壁内的H_1受体的可能性亦不大。鼠
Radiation blocker caused by plasma histamine concentration has long been known. Contrast reactions caused by contrast agents with histamine injection similar to the reaction, although still do not know the real reason, but this similar histamine reaction can only be caused by histamine. In the study of rat aorta, diatrizoate also caused vascular endothelial damage. Blood and contrast agent mixture compared to simple contrast agent damage to the endothelium larger, when experimental carotid angiography, the blood-brain barrier disorders often contradictory phenomenon that the contrast on the contralateral blood-brain barrier infiltration occurs sometimes than the contrast phenomenon Ipsilateral to be much more serious. Such as the use of antihistamine before surgery can completely eliminate the contrast agent is diluted with blood or water after a variety of reactions. The blood and contrast agent-induced damage is very similar to that caused by histamine release. Since antihistamines have no effect on the endothelial leakage caused by pure contrast agents, it is unlikely that the contrast agent will act directly on the H 1 receptor in the aortic wall. mouse