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目的探讨复发性外阴阴道假丝酵母菌病(RVVC)的治疗方法。方法确诊为RVVC的患者82例,用氟康唑加制霉菌素治疗至真菌学转阴后,随机分成2组:治疗组用上述抗真菌巩固后采用阴道乳酸杆菌活菌制剂治疗;对照组连续进行6个月的抗真菌巩固治疗。结果2组近期治愈率差异无显著性;而3个月复发率治疗组明显低于对照组,差异有显著性。结论乳酸杆菌活菌制剂(定君生)能够预防RVVC的复发。
Objective To investigate the treatment of recurrent vulvovaginal candidiasis (RVVC). Methods Eighty-two patients diagnosed with RVVC were treated with fluconazole and nystatin until the mycology turned negative. The patients were randomly divided into two groups: the treatment group was treated with the viable Lactobacillus vaginalis preparations after the anti-fungal consolidation; the control group was continuous Anti-fungal consolidation for 6 months. Results There was no significant difference in the recent cure rates between the two groups. The 3-month recurrence rate was significantly lower in the treatment group than in the control group, with significant difference. Conclusion Live Lactobacillus preparations (Ding Junsheng) can prevent RVVC recurrence.