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目的:探讨皮肤瘢痕样恶性纤维组织细胞瘤(malignant fibrous histiocytoma,MFH)的诊断、误诊原因及预防对策。方法:收集1例皮肤瘢痕样MFH的临床资料,光镜和免疫组化观察并复习文献。结果:组织形态学与“席纹状(storiform)”多形性MFH相同。随访15个月因广泛转移而死亡,第一次会诊结果为非典型纤维组织细胞瘤(Atypical fibrous histiocytoma,AFH),经第二次会诊和后来的病理读片会确诊为皮肤MFH。结论:皮肤瘢痕样MFH非常罕见,临床更凶险,生存期更短。误诊的主要原因是对本病认识不够和鉴别不仔细。
Objective: To investigate the diagnosis, misdiagnosis and prevention of malignant fibrous histiocytoma (MFH) in skin. Methods: One case of skin scar-like MFH was collected and observed by light microscopy and immunohistochemistry. RESULTS: Histomorphology was identical to the “storiform” polymorphic MFH. The follow-up of 15 months due to extensive metastasis and death, the first consultation results for atypical fibrous histiocytoma (Atypical fibrous histiocytoma, AFH), after the second consultation and later pathological reading will be diagnosed as skin MFH. CONCLUSIONS: Skin scar-like MFH is rare and clinically more dangerous with shorter survival. The main reason for misdiagnosis is not enough understanding of the disease and identification is not careful.