论文部分内容阅读
目的探讨阴道放置黄体酮阴道缓释凝胶(商品名:雪诺同8%)在体外受精(IVF)和卵细胞浆内单精子注射(ICSI)术后黄体支持的临床疗效。方法回顾性分析了进行体外受精-胚胎移植(IVF-ET)138个新鲜周期的患者临床资料,按不同黄体支持方法分两组:黄体酮肌内注射组(A组)60例,阴道放置雪诺同8%(B组)78例。观察两组的着床率、临床妊娠率、早期流产率以及药物不良反应发生率。结果 138个新鲜周期中,术后随访期间妊娠共81例,总临床妊娠率为58.7%(81/138),B组的临床妊娠率高于A组的临床妊娠率,差异有统计学意义(P<0.05),B组的不良反应率明显低于A组的不良反应率,差异有统计学意义(P<0.05)。B组的着床率、早期流产率与A组比较,差异均无统计学意义(P>0.05)。结论阴道放置雪诺酮8%在IVF-ET术后进行黄体支持是有效的黄体支持方案,可提高临床妊娠率,且使用简便,可避免患者由于注射黄体酮产生的不良反应。
Objective To investigate the clinical effect of vaginal placement of progesterone vaginal sustained release gel (trade name: Snow Cone 8%) on corpus luteum in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Methods The clinical data of 138 fresh-cycle in vitro fertilization-embryo transfer (IVF-ET) patients were retrospectively analyzed. According to different corpus luteum support methods, 60 cases were treated with progesterone intramuscular injection (group A) Connaught with 8% (group B) 78 cases. The implantation rate, clinical pregnancy rate, early miscarriage rate and incidence of adverse drug reactions in the two groups were observed. Results During the 138 fresh cycles, there were 81 pregnancies during the follow-up period and the total clinical pregnancy rate was 58.7% (81/138). The clinical pregnancy rate in group B was higher than that in group A, with significant difference ( P <0.05). Adverse reaction rate in group B was significantly lower than that in group A, with significant difference (P <0.05). The implantation rate and early abortion rate in group B were not significantly different from those in group A (P> 0.05). CONCLUSIONS: Vaginal placement of 8% of snowballs in corpus luteum after IVF-ET is an effective luteal support protocol that increases clinical pregnancy rates and is simple to use and avoids adverse reactions in patients receiving progesterone.