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Sixty SD rats were fed on diets with lead acetate (PbAc2) at doses of 0, 10, 30, 90,270 and 810 mg/kg for 8 weeks. Blood lead concentration was detected by atomic absorption spectrophotometry and T lymphocyte subsets (CD4. CD8) by the APAAP assay after the exposure. The results showed that levels of blood lead significantly enhanced and the number of CD4 T-cell, the ratio of CD4/CD8 decreased in the experimantal groups, And there was negative correlation between blood lead level and number of CD4 T-cell, the ratio of CD4/CD8. It suggested that long-term lead exposure would exert influence on the distribution of T lymphocyte subsets.
Sixty SD SD rats were fed on diets with lead acetate (PbAc2) at doses of 0, 10, 30, 90, 270 and 810 mg / kg for 8 weeks. Blood lead concentration was detected by atomic absorption spectrophotometry and T lymphocyte subsets (CD4. CD8) by the APAAP assay after the exposure. The results showed that levels of blood lead significantly enhanced and the number of CD4 T-cell, the ratio of CD4 / CD8 decreased in the experimantal groups, And there was negative correlation between blood lead level and number of CD4 T-cell, the ratio of CD4 / CD8. It suggested that long-term lead exposure would exert influence on the distribution of T lymphocyte subsets.