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本文报告27例原发性高血压病人,随机分配作为期10个月的交叉治疗试验,使用螺旋内酯(200毫克/日),心得安(320毫克/日)和两药半量合用,每期2个月,并间隔服用安慰剂2个月。观察血浆肾素活性的不同反应和二种药物对肾素-血管紧张素-醛固酮系统的不同作用。结果表明,单独使用心得安对大多数原发性高血压病人立位或卧位均有明显降压作用。螺旋内酯对肾素活性低或正常的原发性高血压患者有降压作用。二者对肾素-血管紧张素-醛固酮系统有明显的影响。心得安能降低血浆肾素活性,螺旋内酯则使其加强。心得安的降压效果与治疗前的血浆肾素活性有明显关
This article reports 27 patients with essential hypertension randomized to a 10-month crossover study using a combination of spironolactone (200 mg / day), propranolol (320 mg / day) 2 months and placebo at intervals of 2 months. Different responses to plasma renin activity and different effects of the two drugs on the renin-angiotensin-aldosterone system were observed. The results show that the use of propranolol alone for most patients with essential hypertension position or lying down significant antihypertensive effect. Spiral lactone has a hypotensive effect on patients with essential hypertension with low or normal renin activity. Both have a significant effect on the renin - angiotensin - aldosterone system. Adrenaline reduces plasma renin activity, while spirolactone strengthens it. Reliable antihypertensive effect and plasma renin activity before treatment was significantly related