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近年发现,除形成Z盘的骨架蛋白外,还有许多蛋白定位于Z盘,如结合或募集离子通道、Na-Ca交换体、蛋白激酶、蛋白磷酸酶、磷酸二酯酶、蛋白水解酶、组蛋白乙酰转移酶与组蛋白脱乙酰化酶等的蛋白分子,参与了多条信号转导通道的信号调节作用。Z盘还能感知心肌细胞的应力与应变,使结合其上的一些蛋白向核转位,调节基因表达。另外,T管穿行于Z盘之间,可使各类调节信号能快速发挥作用。因此,Z盘部位实质上成为心肌细胞中的信号转导中心。
In recent years, it has been found that in addition to forming the scaffold protein of the Z plate, many proteins are located on the Z plate, such as binding or recruitment of ion channels, Na-Ca exchanger, protein kinase, protein phosphatase, phosphodiesterase, proteolytic enzyme, Histone acetyltransferase and histone deacetylase and other protein molecules, involved in a number of signal transduction pathway signal regulation. Z plate can also sense the stress and strain of cardiomyocytes, so that the binding of some of its proteins to the nucleus, regulating gene expression. In addition, T tube runs between the Z plate, can make all kinds of regulatory signals can quickly play a role. Therefore, the Z site is virtually a signal transduction center in cardiomyocytes.