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作者联合应用抗人胸腺细胞球蛋白(ATG),大剂量甲基强的松龙和羟次甲氢龙治疗46例再障患者(34例重型、12例中型)。ATG毒性反应的早期症状是发热、皮疹、支气管痉挛。23例患者还出现血清病,大剂量激素所产生的并发症包括高血糖,高血压,水潴留,胃肠道出血和髋骨的无菌性坏死。癫痫发作,心律失常和头痛伴视神经乳头水肿的发生也可能与激素有关。有8例患者由于肝功损害不得不停用雄激素。有19例患者血液学获得完全或部分缓解,占41%。有3例复发,其中1例发展为骨髓增生异常综
The authors combined treatment with anti-human thymocyte globulin (ATG), high-dose methylprednisolone and hydroxymethyl-hydrogen dragon treatment of 46 patients with aplastic anemia (34 cases of heavy, 12 cases of medium). Early symptoms of ATG toxicity are fever, rash, bronchospasm. Seropathies also occurred in 23 patients. High-dose hormonal complications include hyperglycemia, hypertension, water retention, gastrointestinal bleeding, and aseptic necrosis of the hip. Epileptic seizures, arrhythmias and headache with optic nerve head edema may also be hormone-related. Eight patients had to discontinue androgens due to liver damage. Hematology was completely or partially resolved in 19 patients (41%). There are three cases of recurrence, one case of myelodysplastic syndrome