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目的探讨PTEN表达与膀胱移行细胞癌生物学行为的关系。方法采用免疫组化SP法检测67例膀胱移行细胞癌和12例正常膀胱粘膜组织中PTEN的表达,按照胞浆内着色程度将染色结果分为阴性、阳性、强阳性三个级别,分析PTEN表达与肿瘤病理分级、临床分期、初发多发、初发复发的关系。结果 PTEN在膀胱移行细胞癌组和正常粘膜组的阳性表达率分别为73.1%和100%,差异具有统计学意义(P<0.05)。PTEN表达随肿瘤病理分级、临床分期升高而下降,呈负相关关系(P<0.05),而在初发组与复发组、单发组与多发组中,PTEN表达未见明显差异。结论 PTEN表达与膀胱癌生物学行为关系密切,检测PTEN表达情况,对于准确评估膀胱移行细胞癌的恶性程度、判断预后有一定帮助。
Objective To investigate the relationship between the expression of PTEN and the biological behavior of bladder transitional cell carcinoma. Methods Immunohistochemical SP method was used to detect the expression of PTEN in 67 cases of transitional cell carcinoma of the bladder and 12 cases of normal bladder mucosa. According to the degree of intracytoplasmic staining, the staining results were divided into three grades: negative, positive and strong positive. PTEN expression And tumor pathological grade, clinical stage, multiple new onset, recurrence of the relationship. Results The positive rates of PTEN in bladder transitional cell carcinoma and normal mucosa were 73.1% and 100%, respectively, with statistical significance (P <0.05). There was a negative correlation between the expression of PTEN and the tumor grade and clinical stage (P <0.05), but there was no significant difference in PTEN expression between the primary group and the recurrent group, the single group and the multiple group. Conclusions The expression of PTEN is closely related to the biological behavior of bladder cancer. Detecting the expression of PTEN may help to evaluate the malignancy of bladder transitional cell carcinoma and prognosis.