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目的 :研究黄芪及丹参注射液与开博通联合应用治疗糖尿病肾病的疗效。方法 :选择糖尿病肾病 32例。其中早期糖尿病肾病 1 9例 ,临床期糖尿病肾病 1 3例 ,每期分为联合用药组及单用开博通对照组。开博通 37.5～ 75mg/d,联合用药组在用开博通的基础上 ,每日静滴黄芪注射液40 ml及丹参注射液 30 ml,并检测 2 4 h尿白蛋白排泄率、肌酐清除率、血 β2 - MG、尿 β2 - MG、血胆固醇、甘油三酯及 HDL。结果 :联合用药可以降低早期糖尿病肾病尿白蛋白排泄率及肌酐清除率效果好于单用开博通组 (P<0 .0 1 ) ,且发现联合用药可以降低临床期糖尿病肾病尿蛋白 ,升高肌酐清除率及 HDL ,降低血胆固醇、甘油三酯、血β2 - MG及尿β2 - MG(P<0 .0 1 )。结论 :本研究证实了中药黄芪、丹参注射液与开博通联合应用治疗糖尿病肾病 ,更有助于改善肾小球滤过率 ,减少尿蛋白 ,疗效好于单用开博通
Objective: To study the curative effect of combination of Astragalus and Salviae Miltiorrhizae and Kaibutong in the treatment of diabetic nephropathy. Methods: 32 cases of diabetic nephropathy were selected. One early diabetic nephropathy in 19 cases, clinical diabetic nephropathy in 13 cases, each divided into the combined group and Kaibutong control group alone. Open Broadon 37.5 ~ 75mg / d, the combination group on the basis of open Broadcom, the daily intravenous infusion Astragalus injection 40 ml and Salvia injection 30 ml, and detect 24 h urinary albumin excretion rate, creatinine clearance Rate, blood β2 - MG, urinary β2 - MG, blood cholesterol, triglycerides and HDL. Results: Combination therapy can reduce the urinary albumin excretion rate and creatinine clearance rate of early diabetic nephropathy better than Kaibutong group (P <0.01), and found that combination therapy can reduce the clinical diabetic nephropathy urine protein, l High creatinine clearance and HDL decreased blood cholesterol, triglycerides, blood β2 - MG and urinary β2 - MG (P <0.01). Conclusion: This study confirmed that Chinese Herbs Astragalus, Salvia injection and Kaibutong combined treatment of diabetic nephropathy, but also help to improve the glomerular filtration rate, reduce urinary protein, the effect is better than single Kaitong