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４周龄雄性大鼠饲缺维生素Ｂ６（ＶＢ６）缺硒酪蛋白蔗糖基础饲料，３周后按体重把动物分成１０组，即基础饲料组、基础饲料中补充含硒０．２５ｍｇ／ｋｇ饲料的硒酸钠组、亚硒酸钠组、ＤＬ－硒蛋氨酸组或硒胱氨酸组，在此基础上每种饲料又分成补充或不补充盐酸吡哆醇２．５０μｇ／ｇ饲料两组。实验期为４周。补ＶＢ６各组的红细胞、骨骼肌和心肌中硒水平和谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性均显著高于相应缺ＶＢ６各组，ＶＢ６对饲硒酸钠、亚硒酸钠和硒胱氨酸大鼠肝硒和ＧＳＨ－Ｐｘ水平没有影响；但当补充硒蛋氨酸时，与补ＶＢ６大鼠相比缺ＶＢ６大鼠的肝硒水平较高而ＧＳＨ－Ｐｘ活性显著降低。本研究结果进一步证明，ＶＢ６与血浆硒的转运和利用有关，并且参与了硒蛋氨酸在肝脏中的代谢过程
Four weeks old male rats were fed with vitamin B6 (VB6), a starved casein sucrose-based diet. After 3 weeks, the animals were divided into 10 groups according to their body weight, namely the basal diet group and the basal diet supplemented with 0.25 mg / kg selenium-containing diet Selenite group, sodium selenite group, DL-selenomethionine group or selenomethionine group. On the basis of this, each feed was divided into two groups: supplemented with or without pyridoxine hydrochloride 2.50μg / g diet. The experiment period is 4 weeks. The levels of selenium and glutathione peroxidase (GSH-Px) in erythrocytes, skeletal muscle and myocardium in VB6 groups were all significantly higher than those in VB6 groups, And selenomethionine had no effect on hepatic selenium and GSH-Px levels. However, when supplemented with selenomethionine, the level of hepatic selenium and the activity of GSH-Px in VB6-deficient rats were significantly lower than those in VB6 rats. The results of this study further prove that VB6 is involved in the transport and utilization of plasma selenium and is involved in the metabolic process of selenomethionine in the liver