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缺氧诱导因子(HIF)是参与缺氧转录反应调控的主要转录因子。HIF-1在心血管生理和病理过程中起重要作用。HIF-1在生理或应激状态下对心肌细胞的大小,结构和功能起着保护作用。在急性心肌缺血、缺血预适应、缺血后适应、缺血-再灌注、急性心肌梗死和压力超负荷诱导心肌肥厚中,HIF-1增加起保护作用;而在慢性心力衰竭过程中、HIF-1增加起恶化作用。HIF-1对心肌的作用与不同疾病或疾病的不同阶段中HIF-1的激活程度、持续时间及靶基因有关。进一步阐明HIF-1在这些疾病过程中的细胞和分子机理将为缺血性心脏病和压力超负荷诱导的心肌重构和心力衰竭的防治提供新的途径。
Hypoxia inducible factor (HIF) is a major transcription factor involved in the regulation of hypoxic transcription. HIF-1 plays an important role in cardiovascular physiology and pathology. HIF-1 plays a protective role in the size, structure and function of cardiomyocytes under physiological or stress conditions. In the process of acute myocardial ischemia, ischemic preconditioning, postischemic adaptation, ischemia-reperfusion, acute myocardial infarction and cardiac hypertrophy induced by pressure overload, HIF-1 increased protective effect. In the process of chronic heart failure, HIF-1 increased to play a deteriorating effect. The effect of HIF-1 on myocardium is related to the activation, duration and target genes of HIF-1 in different stages of different diseases or diseases. Further elucidating the cellular and molecular mechanisms underlying HIF-1 in these diseases will provide new avenues for the management of ischemic heart disease and stress overload-induced myocardial remodeling and heart failure.