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目的探讨重型颅脑损伤患者早期营养支持的临床意义。方法回顾性分析在郑州市第一人民医院治疗的100例重型颅脑损伤患者的临床资料,其中20例早期给予肠内营养(EN)联合肠外营养(PN)营养支持(Ⅰ组);20例早期进行PN,1周后过渡为EN(Ⅱ组);20例早期单纯给予持续2周PN(Ⅲ组);20例早期单纯给予EN(Ⅳ组);20例给予延迟EN(Ⅴ组)。观察五组胃肠功能恢复情况、营养状况以及免疫指标变化。结果Ⅳ组血清白蛋白、血红蛋白和外周血淋巴细胞总数在伤后第7天显著低于Ⅰ、Ⅱ、Ⅲ组(P<0.05)。Ⅴ组伤后第7天和第14天各指标均显著低于Ⅰ、Ⅱ、Ⅲ组(P<0.05)。结论早期给予颅脑损伤患者肠内营养支持结合肠外营养支持有利于改善预后。
Objective To investigate the clinical significance of early nutritional support in patients with severe craniocerebral injury. Methods The clinical data of 100 patients with severe craniocerebral injury who were treated in First People ’s Hospital of Zhengzhou City were retrospectively analyzed. Among them, 20 patients were enrolled in enteral nutrition (PN) nutrition support (Group Ⅰ) 20 (N = 20) were enrolled in this study. Patients were enrolled in this study. Patients were enrolled in this study. Patients were enrolled in this study, . Observed five groups of gastrointestinal function recovery, nutritional status and immune index changes. Results The total serum albumin, hemoglobin and peripheral blood lymphocytes in group Ⅳ were significantly lower than those in groups Ⅰ, Ⅱ and Ⅲ on the 7th day after injury (P <0.05). The indexes of group V on the 7th day and the 14th day were significantly lower than those of the groups Ⅰ, Ⅱ and Ⅲ (P <0.05). Conclusion Early enteral nutrition support combined with parenteral nutrition in patients with craniocerebral injury is beneficial to improve prognosis.