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经一次气管灌注给大鼠染毒０．００８、０．０４、０．２０、０．９８和４．８８ｍｇ／ｋｇ体重铬酸钠（Ｎａ２ＣｒＯ４）后第２天，以及染毒０．９８ｍｇ／ｋｇ体重Ｎａ２ＣｒＯ４后第２、４、７、１０、１４、２１和２８天，分析鼠血和尿液的生化改变，结果提示：０．２０ｍｇ／ｋｇ体重的Ｎａ２ＣｒＯ４可引起急性肾损伤，其恢复过程至少需要１个月，肾损伤的部位主要涉及近曲小管、远曲小管及肾小球；ＮＡＧ、ＬＹＳ和ＡＬＰ可能是评价急性肾损伤最有价值的早期敏感指标。
Rats were exposed to 0.008, 0.04, 0.20, 0.98 and 4.88 mg / kg body weight sodium chromate (Na2CrO4) on the second day after a single tracheal perfusion, and the rats were exposed to 0.98 mg / kg At 2, 4, 7, 10, 14, 21 and 28 days after weight Na2CrO4, the biochemical changes in rat blood and urine were analyzed. The results suggested that 0.20mg / kg body weight of Na2CrO4 could cause acute renal injury, It takes 1 month and the sites of renal injury mainly include proximal convoluted tubule, distal convoluted tubule and glomeruli; NAG, LYS and ALP may be the most valuable early sensitive indicators for evaluating acute kidney injury.