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目的探讨控制超排卵(COH)中获卵数对体外受精-胚胎移植(IVF-ET)妊娠结局的影响,及为避免重度OHSS全胚冷冻的效果。方法接受常规IVF助孕治疗的不孕症患者358例(除外ICSI,Half-ICSI,Re-ICSI)。根据获卵数不同分为3组,其中获卵数1~10者122例(Ⅰ组),获卵数11~20者183例(Ⅱ组),获卵数>20者53例(Ⅲ组);358例中发生OHSS 48例全胚冷冻,其中Ⅰ组无全胚冷冻,Ⅱ组全胚冷冻28例,Ⅲ组全胚冷冻20例。结果全胚冷冻组与新鲜移植组比较:年龄及优胚率无明显差异,着床率及临床妊娠率无明显差异;新鲜移植第Ⅲ组着床率及临床妊娠率低于全胚冷冻第Ⅲ组,差异有显著性。结论 OHSS时全胚冷冻保证了妊娠结局,尤其对获卵数>20的患者有利。
Objective To investigate the effect of controlling ovulation number on the pregnancy outcome of IVF-ET and to avoid the effect of cryopreservation of severe OHSS. Methods A total of 358 infertile patients (except ICSI, Half-ICSI and Re-ICSI) underwent routine IVF assisted pregnancy. According to the number of oocytes obtained, there were 3 groups, of which 122 cases were from 1 to 10 oocytes (group Ⅰ), 183 cases from oocytes from 11 to 20 oocytes (group Ⅱ) ); 48 cases of OHSS 48 cases of whole embryo freezing, which Ⅰ group without whole embryo freezing, Ⅱ group of whole embryo frozen in 28 cases, Ⅲ group 20 cases of whole embryo frozen. Results Compared with the fresh transplantation group, there was no significant difference in age and excellent embryo rate between the whole embryo frozen group and the implantation rate and clinical pregnancy rate. The implantation rate and clinical pregnancy rate of group Ⅲ of fresh transplantation were lower than those of frozen whole-embryo Ⅲ Group, the difference was significant. Conclusion Whole embryo cryopreservation at OHSS ensures pregnancy outcome, especially for those with oocytes> 20.