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目的:比较小剂量红霉素与阿奇霉素序贯治疗婴幼儿支原体肺炎的疗效。方法:按区组随机抽样方法将186例婴幼儿支原体肺炎患儿分为治疗组和对照组各93例。两组在综合治疗的基础上,治疗组给予红霉素10 mg/(kg.d)静脉滴注,每天1次,连用10 d,10 d后改为依托红霉素10 mg/(kg.d)口服,每天2～3次,疗程3周;对照组给予阿奇霉素10 mg/(kg.d)静脉滴注,每天1次,7 d后停4 d,接着口服阿奇霉素干混悬剂10 mg/(kg.d),每天1次,口服3 d停4 d,疗程3周。结果:治疗组总有效率92.47%,对照组总有效率89.25%,两组比较差异无统计学意义(χ2=0.583,P>0.05)。治疗组不良反应发生率17.20%,对照组不良反应发生率18.28%,两组比较差异无统计学意义(P>0.05)。结论:小剂量红霉素治疗婴幼儿支原体肺炎的疗效与阿奇霉素相当,不良反应轻微,依从性较好,值得临床借鉴及进一步观察研究。
Objective: To compare the curative effect of sequential treatment of infant Mycoplasma pneumonia with low dose erythromycin and azithromycin. Methods: A total of 186 infants with mycoplasma pneumonia were divided into treatment group (n = 93) and control group (n = 93) by random sampling method. On the basis of comprehensive treatment, the two groups were given erythromycin 10 mg / (kg.d) intravenously once a day for 10 days, then switched to 10 mg / (kg. d) orally, 2 to 3 times a day for 3 weeks. The control group was given azithromycin 10 mg / (kg.d) intravenously once a day for 4 days after 7 days, followed by oral azithromycin 10 mg /(kg.d), 1 day, oral 3 d stop 4 d, treatment for 3 weeks. Results: The total effective rate was 92.47% in the treatment group and 89.25% in the control group. There was no significant difference between the two groups (χ2 = 0.583, P> 0.05). The incidence of adverse reactions in the treatment group was 17.20%, while the incidence of adverse reactions in the control group was 18.28%. There was no significant difference between the two groups (P> 0.05). Conclusion: The efficacy of low dose erythromycin in infantile mycoplasma pneumonia is equivalent to that of azithromycin, with mild adverse reactions and good compliance. It is worthy of clinical reference and further observation.