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我们已经对某些乙烯基磷酸酯几何异构体的立体专一性合成方法作了报导,本文将讨论借助于异构化反应将低生物活性的异构体转变为高活性体的方法。 含碳—碳双键有机化合物的几何异构化一般是通过热、光和催化剂来实现的,在酸性条件下的异构化法近年来有不少报导。我们在对O,O-二乙基-O-(1-甲基,2-乙氧甲酰基)乙烯基硫代磷酸酯进行豆蚜测定时发现E体的毒力指数为Z体的18倍之多,故Z体向E体的异构化是个值得探讨的问题。J.B.Stothers提出过在紫外光
We have reported the stereospecific synthesis of some of the vinyl phosphate geometric isomers and this article will discuss ways to convert low bioactive isomers to highly active by means of isomerization. Geometric isomerization of organic compounds containing carbon-carbon double bonds is generally achieved by heat, light and catalysts. Isomerization under acidic conditions has been reported in recent years. We found that the virulence index of E was 18 times higher than that of Z when we tested it on O, O-diethyl-O- (1-methyl, 2-ethoxycarbonyl) vinyl phosphorothioate Many, so the Z body to E body isomerization is worth exploring. J.B.Stothers have proposed in the ultraviolet light