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目的了解血清骨型碱性磷酸酶(B-AKP)测定与骨显像联合诊断肿瘤骨转移的价值。方法对136例确诊肿瘤患者作骨型碱性磷酸酶和骨显像的联合检查并进行对比观察。结果在骨转移组,骨显像阳性82例,阳性率95%;在非骨转移组,骨显像阳性6例,假阳性率12%。B-AKP对骨转移诊断阳性率为88%;在非骨转移组阳性率为44%。两组之间测定值及阳性率比较差异均有统计学意义(P<0.001)。结论 B-AKP是诊断骨转移的一个较为有效的生化指标。但它在非骨转移组中的较高阳性率,决定了它在判断骨转移时的局限性,最好与骨显像密切结合,才能更好的做出判断。
Objective To investigate the value of serum bone alkaline phosphatase (B-AKP) assay combined with bone imaging in the diagnosis of bone metastases. Methods A total of 136 patients with confirmed tumor were screened for bone alkaline phosphatase and bone imaging and compared. Results In the bone metastasis group, 82 cases were positive for bone imaging, the positive rate was 95%. In the non-bone metastasis group, 6 cases were positive for bone imaging with a false positive rate of 12%. The positive rate of B-AKP in the diagnosis of bone metastasis was 88%; in non-bone metastasis group, the positive rate was 44%. The difference between the two groups was statistically significant (P <0.001). Conclusions B-AKP is a more effective biochemical marker in the diagnosis of bone metastasis. However, its higher positive rate in non-bone metastasis group determines its limitation in determining bone metastasis, and it is better to closely associate with bone imaging in order to make better judgment.