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目的探讨人乳头状瘤病毒(HPV)的危险因素及不同治疗方法的疗效。方法选取1 000例就诊的妇女进行HPV检查及HPV危险因素的问卷调查,采用单因素和非条件Logistic回归分析HPV感染的危险因素;采用随机数字表法将84例HPV感染阳性患者分为治疗组(42例)和对照组(42例)。治疗组患者采用α干扰素栓进行治疗,对照组患者采用抗宫炎片及阴道冲洗岗松止痒洗剂治疗,比较两组患者的疗效。结果单因素分析结果显示,吸烟、初潮年龄、婚姻状况、饮酒、性伴侣数、首次性生活年龄、性生活频率、丈夫婚外性行为是感染HPV的危险因素(均P<0.05),多因素分析显示,吸烟、初潮年龄、婚姻状况、产次、性伴侣个数、每周性生活频率、丈夫婚外性行为为感染HPV的危险因素(均P<0.05)。治疗组患者总有效率为95.2%,对照组为85.7%,差异有统计学意义(P=0.015);治疗组患者HPV感染转阴率明显高于对照组,差异有统计学意义(P<0.05)。结论HPV感染的危险因素有吸烟、初潮年龄、婚姻状况、产次、性伴侣个数、性生活频率和丈夫婚外性行为;采用α干扰素栓组进行治疗效果优于采用抗宫炎片及阴道冲洗岗松止痒洗剂治疗。
Objective To investigate the risk factors of human papillomavirus (HPV) and the curative effect of different treatment methods. Methods A total of 1 000 women were selected for the HPV test and HPV risk factors questionnaire survey. Univariate and non-conditional logistic regression analysis was used to analyze the risk factors of HPV infection. 84 cases of HPV-positive patients were divided into treatment group (42 cases) and control group (42 cases). Patients in the treatment group were treated with interferon-alpha suppository, while patients in the control group were treated with anti-uterine inflammation tablets and vaginal washing of Gangshen anti-itch lotion, and the curative effect was compared between the two groups. Results The results of univariate analysis showed that smoking, menarche age, marital status, drinking, number of sexual partners, first sex life, frequency of sexual life, husband extramarital sex were the risk factors for HPV infection (all P <0.05), and multiple factors Analysis showed that smoking, menarche age, marital status, parity, the number of sexual partners, frequency of weekly sex, husband’s extra-marital sex as a risk factor for HPV infection (P <0.05). The total effective rate was 95.2% in the treatment group and 85.7% in the control group (P = 0.015). The negative rate of HPV infection in the treatment group was significantly higher than that in the control group (P <0.05) ). Conclusion The risk factors of HPV infection are smoking, age at menarche, marital status, parity, the number of sexual partners, frequency of sexual life and husband’s extramarital sex. The treatment with interferon- Vaginal flushing loose itching lotion treatment.