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展望中国控制甲型肝炎 (甲肝 )之前景 ,考虑与甲肝流行相关的几个问题 :甲肝病毒 (HAV)的致病特点 ;HAV经粪 口途径传播及人群抗体水平状况。控制甲肝流行的有利因素 :HAV的基因结构稳定 ;绝大多数人HAV可归于Ⅰ型 ,株间核苷酸差异 <15 % ,且HAV只有 1个血清型 ,中和抗体可以中和不同基因型的HAV ;中国控制甲肝已取得显著的效果 ,甲肝减毒活疫苗的研究、开发与应用 10余年取得了显著的成就。在理论上甲肝是一种可用疫苗消灭的疾病 ,中国应为此做出贡献。
Looking forward to the prospect of controlling hepatitis A (hepatitis A) in China, we will consider several issues related to the prevalence of hepatitis A: pathogenicity of hepatitis A virus (HAV); transmission of HAV via the fecal oral route and population antibody status. The favorable factors that control the spread of hepatitis A are: the gene structure of HAV is stable; the majority of human HAVs can be classified as type I, the nucleotide differences between strains are less than 15% and only one serotype of HAV is available; neutralizing antibodies can neutralize different genotypes Of the HAV; China has achieved significant results in the control of hepatitis A, live attenuated hepatitis A vaccine research, development and application of more than 10 years made remarkable achievements. In theory, hepatitis A is a vaccine-eradicable disease and China should make its contribution.