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器官特异性肿瘤转移涉及肿瘤细胞与宿主器官特性两大因素，即肿瘤细胞在特定器官微血管内滞留、粘附及血管外实质环境的生长三个环节。由Ｐ选择素，Ｅ选择素，ＩＣＡＭ，ＶＣＡＭ 等粘附分子介导的特定器官微血管内皮细胞，与循环中的肿瘤细胞粘附增强，这是决定器官特异性肿瘤转移复杂而重要的环节。亲和器官内皮下基质成分的异质性参与瘤细胞的运动，器官实质细胞通过旁分泌因子调节肿瘤细胞生长、胶原酶表达、血管形成等，在器官特异性肿瘤转移中亦具有重要意义。
Organ-specific tumor metastasis involves two major factors of tumor cell and host organ characteristics, namely, tumor cell retention, adhesion in specific organs, and growth of extravascular extracellular environment. Specific organ microvascular endothelial cells mediated by adhesion molecules such as Pselectin, Eselectin, ICAM, and VCAM are associated with increased adhesion of circulating tumor cells. This is a complex and important step in determining organ-specific tumor metastasis. . The heterogeneity of the subendothelial matrix of the affinity organ is involved in the movement of the tumor cells. The organ parenchymal cells regulate the growth of tumor cells, collagenase expression, and angiogenesis through paracrine factors, and are also of great significance in organ-specific tumor metastasis.