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目的:研究内皮素-1(ET-1)在喉癌组织中的表达及其意义。方法:采用免疫组织化学SP法检测30例喉癌组织、20例喉良性病变组织及10例喉正常黏膜中ET-1的表达,结合喉癌临床分期进行统计学分析。结果:ET-1在3种组织中的阳性表达均差异有统计学意义(均P<0.05),其中在喉癌组织中表达最高,喉正常组织中表达最低。ET-1在喉癌各临床分期标本中的表达均差异有统计学意义(均P<0.05),分期越晚,表达越高。结论:ET-1在喉癌中呈高表达,对喉癌的发生、发展可能发挥重要作用。
Objective: To investigate the expression of endothelin-1 (ET-1) in laryngeal carcinoma and its significance. Methods: The expression of ET-1 in 30 cases of laryngeal carcinoma, 20 cases of laryngeal benign lesions and 10 cases of laryngeal normal mucosa were detected by immunohistochemical SP method. Statistical analysis was made with clinical staging of laryngeal cancer. Results: The positive expression of ET-1 in all the three tissues was significantly different (all P <0.05). The highest expression was found in laryngeal carcinoma and the lowest in laryngeal normal tissue. The expression of ET-1 in all clinical staging specimens of laryngeal carcinoma was significantly different (all P <0.05), the later the stage, the higher the expression. Conclusion: ET-1 is highly expressed in laryngeal carcinoma and may play an important role in the occurrence and development of laryngeal carcinoma.