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目的观察青刺果黄酮(FPR)对糖尿病小鼠肺病变的影响。方法用四氧嘧啶建立糖尿病小鼠模型,并ig给予300mg.kg-1FPR治疗,连续4周。分别于2、4周末于各组随机抽取4只小鼠宰杀,取出肺脏。肺组织用石蜡切片、HE和Gomori染色、显微镜观测。结果糖尿病小鼠的肺弥漫性出血,肺泡腔缩小,肺泡壁增厚,支气管周围的纤维细胞增生和淋巴细胞浸润,肺间质、支气管周围网状纤维和胶原纤维的含量增加。FPR治疗组小鼠的肺出血得到缓解,肺泡腔增大,肺泡壁基本恢复正常,肺间质、支气管周围有少量的网状纤维和胶原纤维。结论 FPR能明显减轻糖尿病小鼠肺的病理变化,有效延缓糖尿病引起的肺损伤。
Objective To observe the effect of flavonoids from Radix Scutellariae (FPR) on lung lesion in diabetic mice. Methods Diabetic mice model was established by alloxan and treated with ig 300mg.kg-1 FPR for 4 weeks. At the end of 2 and 4 weeks, 4 mice were randomly selected from each group and killed. The lungs were removed. Lung tissue was sectioned with paraffin, stained with HE and Gomori, and observed with a microscope. Results In diabetic mice, diffuse pulmonary hemorrhage, alveolar contraction, thickened alveolar wall, fibroblast proliferation and lymphocyte infiltration around the bronchus, increased interstitial fibrosis and collagen fibers around the bronchus were found in diabetic mice. Pulmonary hemorrhage was relieved in mice treated with FPR, the alveolar space was enlarged, the alveolar wall returned to normal, and a small amount of reticular fibers and collagen fibers around the bronchial stroma were found. Conclusion FPR can significantly reduce the pathological changes of lung in diabetic mice and effectively delay the diabetes-induced lung injury.