人绒毛膜外滋养层Ⅰ类MHC的表达对INF-α的调节有抵抗性

• 作 者: 蔡春友
• 出 处: 国外医学.妇产科学分册
• 发表日期: 1992年04期
• 关键词: 滋养层细胞 人绒毛膜 INF MHC 着床部位 妊娠早期 胚胎成纤维细胞 抵抗性 抗原表达 荧光密度

干扰素(IFN)存在于机体的很多组织中,包括胎盘和着床部位。有报道,IFN-γ能在细胞表面及 mRNA 水平对妊娠早期滋养层细胞的Ⅰ类 MHC抗原的表达有正调节作用。由于子宫内或着床部位有 IFN-α的存在。故就 IFN-α对妊娠早期绒毛膜外滋养层细胞的Ⅰ类 MHC 抗原表达的影响进行研究,发现与 IFN-γ的作用相反,IFN-α对绒毛膜外滋养层细胞Ⅰ类 MHC 抗原的表达无明显影响。而同龄胚胎成纤维细胞对 IFN-α的作用有明显的反应性。

Interferon (IFN) is present in many tissues of the body, including the placenta and implantation site. It has been reported that IFN-γ can positively regulate the expression of MHC class I antigen in trophoblast cells at early stage of pregnancy on the cell surface and mRNA level. Due to intrauterine or implantation sites have the presence of IFN-α. Therefore, the effect of IFN-α on the expression of MHC class Ⅰ antigen in early extraovarial trophoblast cells was studied. It was found that the effect of IFN-α on the expression of MHC class I antigen in trophoblast cells No significant effect. The same age embryonic fibroblasts on the role of IFN-a significant reactivity.