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本文对健康豚鼠于戊巴比妥钠麻醉下,经口给予50%甘油(12m l kg)后分别收集其血清、脑脊液和鼓阶、前庭阶外淋巴液及蜗管内淋巴液,用微量火焰光度法测定钠和钾的浓度。发现在脑脊液、鼓阶、前庭阶外淋巴液和蜗管内淋巴液钠的浓度增加,血清中却无显著变化。这些钠浓度的增加认为是由于甘油渗透作用而引起的脱水。钾浓度增高仅见于鼓阶淋巴液。对比静脉给药法,注射后鼓阶外淋巴液钠的水平出现暂短的高峰,钾含量无变化而蜗管里面内淋巴液钠和钾浓度都未受影响。对照口服甘油后,鼓阶外淋巴液钠的水平出现逐渐持续递增,钾含量上升,蜗管内淋巴液钠浓度见升高,钾含量显示有意义的轻度增加。
In this study, healthy guinea pigs were anesthetized with pentobarbital, 50% glycerol (12ml) was orally administered to collect their serum, cerebrospinal fluid and scala tympani, vestibular extranodal and cochlear lymphatic fluid, respectively, with trace flame photometry Determination of sodium and potassium concentration. Found in the cerebrospinal fluid, scala tympani, vestibular extranodal and cochlear lymphatic fluid sodium concentration increased, but no significant changes in serum. These increases in sodium concentration are believed to be due to dehydration caused by glycerol permeation. Potassium concentration increased only in the drum stage lymph. In contrast to intravenous administration, the levels of Na in the extra-bulbar lymphoid tissue appeared transiently shortened after injection, while there was no change in the potassium content. Both the sodium and potassium concentrations in the lymphatic fluid were unaffected. After oral administration of glycerol, the level of extraglular lymphatic fluid gradually increased gradually, the potassium content increased, and the content of sodium in the cochlea increased, while the content of potassium showed a significant and slight increase.