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目的探讨下咽癌手术+术后放疗的临床疗效及影响下咽癌生存率和局控率的因素。方法回顾性分析1979年2月￣2001年4月收治的手术+术后放疗下咽癌78例,Kaplan-Meier法分析3、5年生存率和局控率,Logrank进行单因素分析,Cox模型进行多因素分析。结果60例手术+术后下咽癌放疗下咽癌病人3、5年生存率分别为58.1%和41.9%,3、5年局控率分别为82.3%和75.6%。多因素分析显示T分期,N分期以及临床分期是影响下咽癌生存率的独立预后因素;T分期和临床分期是影响下咽癌局控率的独立预后因素。结论T分期,N分期和临床分期是影响下咽癌长期生存的独立预后因子,T分期和临床分期是影响下咽癌局控率的独立预后因子。
Objective To investigate the clinical efficacy of hypopharyngeal cancer surgery and postoperative radiotherapy and the factors influencing the survival rate and control rate of pharyngeal cancer. Methods A retrospective analysis of 78 patients with pharyngeal carcinoma underwent surgery + radiotherapy after surgery from February 1979 to April 2001 was performed. Kaplan-Meier method was used to analyze the 3-year and 5-year survival rates and the control rate. Logrank was used to perform univariate analysis. Cox model Multivariate analysis. Results The 3-year and 5-year survival rates of 60 patients with surgery for pharyngeal carcinoma and those with hypopharyngeal cancer under radiation therapy were 58.1% and 41.9% respectively. The local control rates at 3 and 5 years were 82.3% and 75.6% respectively. Multivariate analysis showed that T stage, N stage and clinical stage were the independent prognostic factors affecting the survival rate of hypopharyngeal carcinoma. T stage and clinical stage were the independent prognostic factors affecting the control rate of hypopharyngeal cancer. Conclusion T stage, N stage and clinical stage are the independent prognostic factors that affect the long-term survival of hypopharyngeal carcinoma. T stage and clinical stage are the independent prognostic factors that affect the control rate of hypopharyngeal cancer.