论文部分内容阅读
目的参照《非手术治疗食管癌的临床分期标准(草案)》对首程接受根治性放疗的191例食管癌患者分期,进行预后分析与评价,探讨此分期的实用性、预测价值及不足之处。方法 2009年5月至2012年5月在郑州大学附属肿瘤医院首程接受根治性放疗的191例食管癌患者,依据临床分期标准将其分为各个亚组,其中T1期8例、T2期54例、T3期77例、T4期52例,N0期68例、N1期81例、N2期42例,M0期172例、M1期19例,TNMⅠ期29例、Ⅱ期80例、Ⅲ期63例、Ⅳ期19例。观察其近期疗效、生存率、局部控制率、治疗失败原因,并进行预后评价。结果全组1、2、3年局部控制率分别为83.2%、62.3%、48.7%,生存率分别为64.9%、36.6%、30.2%,中位生存期16个月。Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者1、2、3年生存率分别为89.7%、60.3%、48.2%,63.8%、38.2%、25.8%,58.7%、26.7%、20.8%,47.4%、12.6%、0(χ2=14.353,P=0.002),而每一期别各亚组之间生存率比较差异均未见统计学意义(χ2值分别为0.605、6.874、2.988、12.985,P值分别为0.437、0.076、0.560、0.059)。结论《非手术治疗食管癌的临床分期标准(草案)》能够较为准确地反映食管癌放疗患者的预后情况,分期修改方案细节之处有待进一步完善。
Objective To evaluate the prognosis and prognosis of 191 patients with esophageal cancer who underwent radical radiotherapy for the first time according to the “Staging Criteria for Non-surgical Treatment of Esophageal Cancer” (draft), discuss the practicality, predictive value and shortcomings of this staging . Methods From May 2009 to May 2012, 191 patients with esophageal cancer who underwent radical radiotherapy for the first time at the Affiliated Tumor Hospital of Zhengzhou University were divided into various subgroups according to the clinical staging criteria, including 8 cases in T1, 54 cases in T2 For example, there are 77 cases in stage T3, 77 in stage T4, 68 in stage N0, 81 in stage N1, 42 in stage N2, 172 in stage M0, 19 in stage M1, 29 in stage I, 80 in stage II, and 63 in stage III Cases, 19 cases of stage Ⅳ. To observe the short-term efficacy, survival rate, local control rate, the cause of treatment failure, and prognosis. Results The local control rates at 1, 2 and 3 years were 83.2%, 62.3% and 48.7% respectively. The overall survival rates were 64.9%, 36.6% and 30.2% respectively, and the median survival time was 16 months. The 1, 2, 3 year survival rates were 89.7%, 60.3%, 48.2%, 63.8%, 38.2%, 25.8%, 58.7%, 26.7%, 20.8%, 47.4%, 12.6 %, 0 (χ2 = 14.353, P = 0.002). There was no significant difference in the survival rates between each subgroup (χ2 = 0.605,6.874,2.988,12.985, P = 0.476, 0.060, 0.059). Conclusion “The non-surgical treatment of esophageal cancer clinical staging criteria (draft)” can accurately reflect the prognosis of patients with esophageal cancer radiotherapy, staging to modify the program details to be further improved.